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Author Topic: Why Marijuana is Gravely Sinful  (Read 30409 times)

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Offline Mark 79

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Re: Why Marijuana is Gravely Sinful
« Reply #165 on: April 22, 2022, 01:57:56 AM »

Chronic marijuana use…



The title says: "Chronic marijuana use negatively impacts male reproductive health"


and the article says:

Chronic use of marijuana may greatly impact male fertility and reproductive outcomes, says a new report published online in the journal Fertility & Sterility. The study is the first to assess the impacts of substance use on testicular function via a mode of delivery, and dosage, that reflects current human consumption.

[EXCEPT THEY DIDN'T STUDY HUMANS]


Quote
Clinician-scientists at the Oregon National Primate Research Center at Oregon Health & Science University, monitored the reproductive systems of healthy male nonhuman primates following exposure to Delta-9-tetrahydrocannabinol, or THC — the main psychoactive ingredient in marijuana.

… [wait for it] “While more research is necessary to better understand the potential long-term impacts of THC in humans, these early findings are concerning from a clinical standpoint,” ……… [blah, blah, blah]



I'm surprised they didn't cite Tweets from Twitter.



Meanwhile the ignorati fail to  have noticed a dramatic continuing global decrease in human fertility for about 70 years. https://www.shareradio.co.uk/media/7509/bbc-fertility-rate-150720.pdf

The phenomenon is noticed from China and Japan through Nigeria and the USA.

Maybe China, Japan, and Nigeria have also been awash with a marijuana pandemic for 70 years, but nobody noticed???

:facepalm:

Offline Mark 79

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Re: Why Marijuana is Gravely Sinful
« Reply #166 on: April 22, 2022, 02:22:18 AM »
Also the test doses on the monkeys started at a dose equivalent to an average (70kg) man taking 10mg every day.

Since micro-dosing is generally in the 2 to 5mg range, the monkeys were given a starting daily dose that is 2 to 5 times greater than the micro-dosing we have been discussing.

The non-paywalled portion of the article does not say how much higher the dosing went to get the results they claim. At $31.50 I won't buy access to an article that doesn't pass the most basic methodological scrutiny.


Online Ladislaus

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Re: Why Marijuana is Gravely Sinful
« Reply #167 on: April 22, 2022, 10:17:53 AM »
10 mg is reported to be ROUGHLY the threshold at which human beings might experience psychoactive effects (i.e. a bit of a buzz or high).

Offline Mark 79

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Re: Why Marijuana is Gravely Sinful
« Reply #168 on: April 22, 2022, 11:23:59 AM »
Yes, roughly. That is why the article's starting dose disqualifies it as evidence against appropriate medical use or social use within the bounds of Catholic moral theology.

There is also an interesting blind spot (so surprised!) in the researchers' assumptions. In the non-paywalled portion available online, the researchers only refer to MJ down-regulating the hypthalamic-pituitary-gonadal axis, but that is a bogus assumption.

As I described in the Endocannabinoid thread, the Encdocannabinoid System ("ECS" in the article) is quite unique from other neurotransmitter systems. Re-read that article to understand that the ECS is a post-synaptic release that seeks homeostasis; over-active components are down-regulated and under-active components are up-regulated. Hence, the many hundreds of MJ chemiocals (why researchers studying one chemical, THC, cannot paint an honest picture of MJ use) can either up-regulate or down-regulate fertility (as it does with the dozens of other ECS components like bone density, mood, etc.).

Phytocannabinoids (see that thread) behave similarly, up-regulate where needed and down-regulate where needed. Another topic in which I have been interested is placental (not a baby, songbird, but the afterbirth previously discarded) stem cells. Stem cells, like MJ, enhance homeostasis—by different mechanisms than MJ, but still promote health by up-regulating or down-regulating as the body's healing systems need.

Offline Mark 79

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nut case
« Reply #169 on: April 22, 2022, 12:43:03 PM »