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"The findings suggest that the Marek's vaccine encourages more dangerous viruses to proliferate. This increased virulence might then give the viruses the means to overcome birds' vaccine-primed immune responses and sicken vaccinated flocks."
"You may have heard that bacteria can develop resistance to antibiotics and, in a worst-case scenario, render the drugs useless. Something similar can also happen with vaccines, though, with less serious consequences.
This worry has arisen mostly in the debate over whether to delay a second vaccine shot so more people can get the first shot quickly. Paul Bieniasz, a Howard Hughes investigator at the Rockefeller University, says that gap would leave people with only partial immunity for longer than necessary."
"This evolutionary pressure is present for any vaccine that doesn't completely block infection … Many vaccines, apparently, including the COVID vaccines, do not completely prevent a virus from multiplying inside someone even though these vaccines do prevent serious illness."
"It's quite normal for RNA viruses like SARS-CoV-2, when it replicates, to make typographical errors," Yeadon explains. "It's got a very good error detection, error correction system so it doesn't make too many typos, but it does make some, and those are called 'variants.'
It's really important to know that if you find the variant that's most different from the sequence identified in Wuhan, that variance … is only 0.3% different from the original sequence.
I'll say it another way. If you find the most different variance, it's 99.7% identical to the original one, and I can assure you … that amount of difference is absolutely NOT possibly able to represent itself to you as a different virus."
"When your government scientists tell you that a variant that's 0.3% different from SARS-CoV-2 could masquerade as a new virus and be a threat to your health, you should know, and I'm telling you, they are lying," Yeadon says.
"If they're lying, and they are, why is the pharmaceutical industry making top-up [booster] vaccines? … There's absolutely no possible justification for their manufacture."
"Annual COVID booster shots are music to the ears of investors. But some independent scientists warn16 that trying to outsmart the virus with booster shots designed to address the next variant could backfire, creating an endless wave of new variants, each more virulent and transmissible than the one before …
According to Rob Verkerk Ph.D., founder, scientific and executive director of Alliance for Natural Health International, variants can become more virulent and transmissible, while also including immune (or vaccine) escape mutations if we continue on the vaccine treadmill — trying to develop new vaccines that outsmart the virus.
Verkerk said 'if we put all our eggs' in the basket of vaccines that target the very part of the virus that is most subject to mutation, we place a sɛƖɛctıon pressure on the virus that favors the development of immune escape variants."
"There can be no doubt that continued mass vaccination campaigns will enable new, more infectious viral variants to become increasingly dominant and ultimately result in a dramatic incline in new cases despite enhanced vaccine coverage rates. There can be no doubt either that this situation will soon lead to complete resistance of circulating variants to the current vaccines," Bossche wrote.19
"2020: A 14-year study finds that influenza vaccines are associated with an 8.9% increase in the risk of all-cause mortality in elderly men … During six A/H3N2-predominant seasons their all-cause mortality increase was 16.6%! …
The unfortunate history of influenza vaccines should warn us against repeating the process with Covid-19 vaccines. Peter Doshi may be understating the case when he suggests that influenza vaccines have not saved lives. The foregoing history and other observations suggest that in whole populations over the long run seasonal flu campaigns have actually cost lives …
This idea is hard to grasp in the face of massive publicity and reports of 'vaccine effectiveness.' The vaccines provide modest short-term protection against seasonal flu, but the VE studies completely ignore adverse effects (e.g. high fever, seizures, narcolepsy, oculo-respiratory syndrome, Guillain-Barre syndrome) … We don't need another vaccine treadmill that could do more harm than good."
"Recent research suggests … that some pathogen populations are adapting in ways that help them survive in a vaccinated world … Just as the mammal population exploded after dinosaurs went extinct because a big niche opened up for them, some microbes have swept in to take the place of competitors eliminated by vaccines.
Immunization is also making once-rare or nonexistent genetic variants of pathogens more prevalent, presumably because vaccine-primed antibodies can't as easily recognize and attack shape-shifters that look different from vaccine strains.
And vaccines being developed against some of the world's wilier pathogens — malaria, HIV, anthrax — are based on strategies that could, according to evolutionary models and lab experiments, encourage pathogens to become even more dangerous.24 Evolutionary biologists aren't surprised that this is happening.
A vaccine is a novel sɛƖɛctıon pressure placed on a pathogen, and if the vaccine does not eradicate its target completely, then the remaining pathogens with the greatest fitness — those able to survive, somehow, in an immunized world — will become more common.
'If you don't have these pathogens evolving in response to vaccines,' said Paul Ewald, an evolutionary biologist at the University of Louisville, 'then we really don't understand natural sɛƖɛctıon.'"
"'Mutants of concern' are clearly on most of our radars. An important question is: are they growing or declining in frequency? In some countries, including ones where vaccinations have occurred at a high rate … they are increasing and have already become dominant … That should be a very large, flappy, red flag to anyone who has a reasonable grasp of evolutionary sɛƖɛctıon pressure on viruses with pathogenic capacity.
More infection — including more silent infection among asymptomatic people (even if reduced by vaccination) — provides more opportunities for mutation. If we continue to drag out the time it takes for the virus to just become another endemic component of our virosphere, there will be more opportunities and more mutations. Not dissimilar to a game of Russian roulette — so why don't we start counting our chances?
If variants become both more transmissible and more virulent, while also including immune (or vaccine) escape mutations — all trends we are witnessing in some parts of the world — we could be in deep trouble down the road.
At the very least, we stay on the vaccine (or monoclonal antibody) treadmill, trying to develop new vaccines (or monoclonal antibody therapies) that outsmart the virus when we should know better; that the virus will continue to outsmart us if we maintain such intense sɛƖɛctıon pressure on it …
Let me throw in one more concept that is ecological in nature: herd immunity. The base equation used by government scientists that estimates around 70% of the population need to be vaccinated or exposed to the virus to achieve herd immunity is flawed.
It is predicated on a number of assumptions that don't apply: equal mixing of populations and successful sterilization of the virus in vaccinated people and those exposed to wild virus being just two. This just isn't the case. In the real world, the situation is much more complex than in an idealized model.
Randolph and Barreiro remind us in their review26 in the journal Immunity that '[e]pidemiological and immunological factors, such as population structure, variation in transmission dynamics between populations, and waning immunity, will lead to variation in the extent of indirect protection conferred by herd immunity.'
For vaccinated people, antigen-specific antibodies bind firmly to virus particles and competitively oust natural antibodies, giving vaccinated people potentially less cross-immunity to mutant variants that are more infectious and the wave of infectivity continues."