The way I look at it a housewife who wants a business would want one that didn't take too much of her time, had almost no legal ramifications, didn't take her out of the house much, but kept her doing something and reliably earning several thousand dollars per year for her family. One of the best ways to do this is to pick up a simple skill and then vend your wares online or perhaps at a local market.
It could be anything from refurbishing kitchen antiques like kettles, to basic leatherworking or knitting (using reclaimed materials is a good hook), to candle-making or baking. You shouldn't pigeonhole yourself by thinking that because you're college educated you should have a certain kind of business. It just means you have brains that might help you plan and run the thing well.
It's a good topic and one that I'd like to explore more. Can you give any more information about your goals?