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Author Topic: High-profile researcher admits fabricating scientific results published  (Read 2546 times)

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Offline Croix de Fer

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    A high-profile scientist who spearheaded a campaign on medical research has admitted to fabricating research published in two international journals.

    A number of papers written by Dr Anna Ahimastos have been withdrawn from the Journal of the American Medical Association (JAMA) and a journal published by the American Heart Association.

    Dr Ahimastos was working for Melbourne's prestigious Baker IDI Heart and Diabetes Institute at the time.

    She has admitted to making up some of the data in the study, and has resigned.

    The paper looked at whether Ramipril or Prilace, a well-known blood pressure drug, could help people with peripheral artery disease to walk pain free.

    The study had found that after almost six months on the drug, patients could walk without pain for maximum periods of time on a treadmill.

    Two journals, JAMA and Circulation Research, both said the paper was retracted after an internal analysis by Baker IDI Heart and Diabetes Institute "revealed anomalies that triggered an investigation which resulted in an admission of fabricated results by Dr Ahimastos".

    Actions compromised study: Baker

    Dr Bronwyn Kingwell, from the Baker IDI Heart and Diabetes Institute, said the organisation took action as soon as the fabrication came to light.

    "Dr Ahimastos admitted to fabricating records for some patients," she said.

    Specifically, Dr Ahimastos made up data about trial participants that did not exist.

    "These actions compromised the overall findings of the study and so we moved quickly to correct the public record by retracting the relevant papers," Dr Kingwell said.

    "The institute does take these matters very seriously and every effort has been made to correct the record and contact all affected parties as quickly as possible."

    She said the main results from the retracted JAMA study had since been corroborated in a small clinical trial.

    Dr Ahimastos is a member of the Australian Society for Medical Research and is involved in science communication.

    She was also named a Tall Poppy — an Australian Institute of Policy and Science campaign which recognises scientific excellence — in Victoria in 2010.

    According to Research Gate, Dr Ahimastos is listed as an author on 23 publications and the paper in question has been cited 35 times.

    Dr Ahimastos did not respond to the ABC's inquiries.
    Authors apologise, vow to strengthen audit procedures

    A statement published in the two journals said Dr Ahimastos was solely responsible for data collection and integrity of the study.

    "According to the institute's findings, no co-authors were involved in this misrepresentation," it stated.

    "In addition, no data from the Townsville and Brisbane recruitment centres were included in this publication and data from those centres remains valid."

    The authors of the paper have apologised and the Baker IDI Heart and Diabetes Institute has vowed to strengthen its governance and audit procedures to minimise the chance of it happening again.

    'Publish-or-perish' research culture

    Dr Virginia Barbour, the chair of the Committee on Publication Ethics, said while corrections were fairly common in academic journals, a full retraction of a paper was more rare.

    "If you talk to academics nowadays, there is a real publish-or-perish culture," she said.

    "A study in the UK last year found ... researchers explicitly said the pressure to publish led them to cut corners, which is a pretty alarming finding.

    "We do feel one of the problems is that authors are pressured to publish, and publish in very high journals."

    She said there were cases of substantial misconduct where grants had to be handed back.
    Blessed be the Lord my God, who teacheth my hands to fight, and my fingers to war. ~ Psalms 143:1 (Douay-Rheims)


    Offline Croix de Fer

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    High-profile researcher admits fabricating scientific results published
    « Reply #1 on: September 17, 2015, 01:19:03 PM »
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    Why Most Published Research Findings Are False

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    Abstract
    Summary

    There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this essay, I discuss the implications of these problems for the conduct and interpretation of research.

    Published research findings are sometimes refuted by subsequent evidence, with ensuing confusion and disappointment. Refutation and controversy is seen across the range of research designs, from clinical trials and traditional epidemiological studies [1–3] to the most modern molecular research [4,5]. There is increasing concern that in modern research, false findings may be the majority or even the vast majority of published research claims [6–8]. However, this should not be surprising. It can be proven that most claimed research findings are false. Here I will examine the key factors that influence this problem and some corollaries thereof.

    [...]



    Blessed be the Lord my God, who teacheth my hands to fight, and my fingers to war. ~ Psalms 143:1 (Douay-Rheims)


    Offline Croix de Fer

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    High-profile researcher admits fabricating scientific results published
    « Reply #2 on: September 17, 2015, 01:22:52 PM »
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  • US scientists significantly more likely to publish fake research, study finds

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    US scientists are significantly more likely to publish fake research than scientists from elsewhere, finds a trawl of officially withdrawn (retracted) studies, published online in the Journal of Medical Ethics.

    Fraudsters are also more likely to be "repeat offenders," the study shows.

    The study author searched the PubMed database for every scientific research paper that had been withdrawn -- and therefore officially expunged from the public record -- between 2000 and 2010.

    A total of 788 papers had been retracted during this period. Around three quarters of these papers had been withdrawn because of a serious error (545); the rest of the retractions were attributed to fraud (data fabrication or falsification).

    The highest number of retracted papers were written by US first authors (260), accounting for a third of the total. One in three of these was attributed to fraud.

    The UK, India, Japan, and China each had more than 40 papers withdrawn during the decade. Asian nations, including South Korea, accounted for 30% of retractions. Of these, one in four was attributed to fraud.

    The fakes were more likely to appear in leading publications with a high "impact factor." This is a measure of how often research is cited in other peer reviewed journals.

    More than half (53%) of the faked research papers had been written by a first author who was a "repeat offender." This was the case in only one in five (18%) of the erroneous papers.

    The average number of authors on all retracted papers was three, but some had 10 or more. Faked research papers were significantly more likely to have multiple authors.

    Each first author who was a repeat fraudster had an average of six co-authors, each of whom had had another three retractions.

    "The duplicity of some authors is cause for concern," comments the author. Retraction is the strongest sanction that can be applied to published research, but currently, "[it] is a very blunt instrument used for offences both gravely serious and trivial."


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    Abstract

    Background Papers retracted for fraud (data fabrication or data falsification) may represent a deliberate effort to deceive, a motivation fundamentally different from papers retracted for error. It is hypothesised that fraudulent authors target journals with a high impact factor (IF), have other fraudulent publications, diffuse responsibility across many co-authors, delay retracting fraudulent papers and publish from countries with a weak research infrastructure.

    Methods All 788 English language research papers retracted from the PubMed database between 2000 and 2010 were evaluated. Data pertinent to each retracted paper were abstracted from the paper and the reasons for retraction were derived from the retraction notice and dichotomised as fraud or error. Data for each retracted article were entered in an Excel spreadsheet for analysis.

    Results Journal IF was higher for fraudulent papers (p<0.001). Roughly 53% of fraudulent papers were written by a first author who had written other retracted papers (‘repeat offender’), whereas only 18% of erroneous papers were written by a repeat offender (&#967;=88.40; p<0.0001). Fraudulent papers had more authors (p<0.001) and were retracted more slowly than erroneous papers (p<0.005). Surprisingly, there was significantly more fraud than error among retracted papers from the USA (&#967;2=8.71; p<0.05) compared with the rest of the world.

    Conclusions This study reports evidence consistent with the ‘deliberate fraud’ hypothesis. The results suggest that papers retracted because of data fabrication or falsification represent a calculated effort to deceive. It is inferred that such behaviour is neither naïve, feckless nor inadvertent.
    Blessed be the Lord my God, who teacheth my hands to fight, and my fingers to war. ~ Psalms 143:1 (Douay-Rheims)

    Offline Jehanne

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    High-profile researcher admits fabricating scientific results published
    « Reply #3 on: September 22, 2015, 05:37:28 AM »
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  • Quote from: ascent
    Two journals, JAMA and Circulation Research, both said the paper was retracted after an internal analysis by Baker IDI Heart and Diabetes Institute "revealed anomalies that triggered an investigation which resulted in an admission of fabricated results by Dr Ahimastos".


    Yeah, people lie, even scientists.  So what?!  Point is that the scientific method guarantees that the truth will come out, eventually.

    Offline Croix de Fer

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    High-profile researcher admits fabricating scientific results published
    « Reply #4 on: September 22, 2015, 07:27:42 AM »
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  • Quote from: Jehanne

    Yeah, people lie, even scientists.  So what?!  Point is that the scientific method guarantees that the truth will come out, eventually.


     :facepalm:


    Take heed:

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    Scientists recently discovered that people will believe anything if scientists say they discovered it. :wink:
     

    But the overshadowing point, here, is the fact that science will be used by Satan to deceive man and help usher in the anti-Christ.

    Too many sheeple take "science" as dogmatic truth. Their (lib-tards, atheists, humanists, agnostics, et al) "bibles" are peer review studies and academic journals.  :laugh2:
    Blessed be the Lord my God, who teacheth my hands to fight, and my fingers to war. ~ Psalms 143:1 (Douay-Rheims)


    Offline Neil Obstat

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    High-profile researcher admits fabricating scientific results published
    « Reply #5 on: September 22, 2015, 08:01:17 AM »
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    the scientific method guarantees that the truth will come out, eventually.


    Update:

    Scientists doing peer reviewed studies don't use the scientific method anymore. They are told in advance what the outcomes need to be and they conduct their "research" accordingly, to get the desired results, or else they don't get funding.

    Bottom line is, if they get funding, they must be doing something right.

    The scientific method has nothing to do with it.

    .
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    Offline Beverly

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    High-profile researcher admits fabricating scientific results published
    « Reply #6 on: September 22, 2015, 09:25:01 AM »
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  • Dr. Mercola Interviews Dr. Kendrick About Medical Fraud

    https://www.youtube.com/watch?t=26&v=s9-33PrPdoQ

    There’s so much confusion regarding health information in the media. How do you determine which advice to follow and what to take with a grain of salt? Dr. Malcolm Kendrick wrote the book Doctoring Data: How to Sort Out Medical Advice from Medical Nonsense to help you answer that question.

    His fabulous book will teach you how to identify common research flaws and help you sift through misleading and meaningless data. An important resource if you are a serious student of health.

    Dr. Kendrick has also written The Great Cholesterol Con: The Truth about What Really Causes Heart Disease and How to Avoid It, which is another great book. Like me, he’s a trained family doctor whose journey led him to abandon much of what’s promoted in conventional medicine

    Many Times They Just Make Stuff Up

        While it’s hard to comprehend, some health recommendations are completely fabricated and are not based in any science. Dr. Kendrick wrote about this in a recent article for The Independent:1

            “If you are a man, it has virtually become gospel that drinking more than 21 units of alcohol a week is damaging to your health. But where did the evidence to support this well-known ‘fact’ come from?

            The answer may surprise you. According to Richard Smith, a former editor of the British Medical Journal, the level for safe drinking was ‘plucked out of the air.’

            He was on a Royal College of Physicians team that helped produce the guidelines in 1987. He told The Times newspaper that the committee's epidemiologist had conceded that there was no data about safe limits available and that ‘it's impossible to say what's safe and what isn't.’

            Smith said the drinking limits were ‘not based on any firm evidence at all,’ but were an ‘intelligent guess.’ In time, the intelligent guess becomes an undisputed fact.”

        According to Dr. Kendrick, the linear model for blood pressure—which states the higher your blood pressure is, in a linear fashion, the greater your risk of dying—was also made up.

        Ditto for recommended cholesterol levels, and healthy versus unhealthy obesity levels. Believe it or not, none of these are based on real data. The recommendation to eat five portions of fruit and vegetables is equally made up, yet recommendations such as these become set in stone.

        People believe it must be based on solid evidence and therefore true. One of the most impressive comments he made in the interview is: “Don’t believe it. They just made it up.”

    Absolute Risk versus Relative Risk, and Number Needed to Treat

        Absolute risk versus relative risk can be used to make something sound far worse than it really is, or conversely, make something appear better than it is. Most doctors even struggle to understand what these two terms actually mean. Dr. Kendrick explains absolute versus relative risk with the following example:

            “You get 100 people and you put them on a blood pressure-lowering medication, and you get 100 people and put them on a placebo. After a year, two people have died in the placebo group; one person has died in the blood pressure-lowering group.

            That’s an absolute difference of one percent [one out of 100], and a relative difference of one death versus two; that’s 50 percent.

            Now, take 1,000 people and do the same. In the thousand-people group, one person dies in the blood pressure arm and two people die in the placebo arm. The difference is absolute: It’s 0.1 percent. The relative risk difference is one versus two—it’s 50 percent...

            When it comes to things like statins, which they say reduces the risk of heart disease by 40 percent, you say, ‘What was the underlying risk? Was it one in 10,000, one in two, one in a million?’ Unless you know that, the statistic is meaningless. I think relative risk should never be mentioned in any clinical study. It should be absolute risk all the time. [Relative risk] is the standard, and it shouldn’t be because it’s just ridiculous.”

    Overall Mortality versus Specific Cause of Death

        Another way medical findings can be twisted is by focusing on the prevention of specific causes of death. For example, a study might claim that a cholesterol-lowering drug reduces the risk of dying from heart disease, but the people in the study may have died in greater numbers from other health problems instead. Naturally, you cannot die from heart disease if you die from another disease first. As a result, some research ends up forming the basis for health recommendations that actually do more harm than good.

            “It’s the overall mortality you have to look at—ALL causes of possible death. What was the impact? When you look at, say, alcohol consumption, it increases the risk of mouth cancer, esophageal cancer, stomach cancer... But when you look at the overall figures, it reduces the overall mortality risk. So you can take all of these things, add them together, and basically ignore them on the basis that you’re going to have to die of something,” Dr. Kendrick says.

        Another perfect example is sun exposure.

            “Dermatologists have taken over the world on sun exposure and said, ‘Oh, people are getting skin cancer so you must never allow a photon go straight to your skin.’ To which I say, I’ve seen studies where women who have higher sun exposure are 50 percent less likely to get breast cancer.

            Men who have higher rates of sun exposure have are 50 percent less likely to get aggressive prostate cancer. Men and women who have higher rates of sun exposure are 75 percent less likely to get colorectal cancer... Frankly, the research I’ve looked at says sun exposure protects against malignant melanoma; it doesn’t cause it. Therefore the whole thing is a crock.”

        Sun exposure also protects against heart disease, improves bone strength, reduces osteoporosis, and reduces your chance of developing multiple sclerosis and Parkinson’s disease. Does it raise your risk of deadly skin cancer? If you get burned, yes, it may, but the overall health benefits FAR outweigh the potentially elevated risk of melanoma. Part of the problem is you cannot see that which does not happen.

        If you tan and get melanoma, your dermatologist will tell you it’s your fault for not following his recommendations to stay out of the sun. But if you never come down with colorectal cancer, no one will pat you on the back and say, “Great job! You successfully avoided cancer because you spent so much time in the sun.”

    Longest Running Study in the World Refutes Conventional ‘Facts’

        One of the examples in Dr. Kendrick’s book is the Framingham Study, which was one of the longest studies ever done in the world. It has been going on for about seven decades. One of the conclusions reached was that people whose cholesterol was reduced by one millimole per liter, which equates to about 40 milligram per deciliter, raised their risk of dying of heart disease in the next 14 years by 500 percent.

        Falling cholesterol was determined to be the most important risk factor for heart disease mortality in this study, yet this finding has received virtually no publicity, as it runs contrary to conventional recommendations to lower your cholesterol to prevent heart disease. They also discovered that the more saturated fat people ate, the lower their cholesterol level was during the length of the study. This too is completely contrary to conventional recommendations to avoid saturated fat because it raises your cholesterol.

        Mammography is another area where science and “conventional wisdom” is often at odds. Dr. Peter C. Gotzsche, a professor of Clinical Research Design and Analysis, and director of the Nordic Cochrane Centre, wrote an excellent book on this subject called Mammography Screening: Truth, Lies, and Controversy. After studying it for years, he came to the conclusion that mammography probably does more harm than good.

        The Cochrane Collaboration, by the way, is a worldwide effort of researchers who have no industry connections, who collaborate to review and evaluate available evidence on any given topic and then come to a conclusion. The Cochrane Database the gold standard for objective, impartial, non-biased meta-reviews.

    Non-Disclosure of Negative Data and Other Shenanigans

        Other common tactics of misdirection include the non-disclosure of negative studies and good old-fashioned conflicts of interest. As noted by Dr. Kendrick: “In the States, they have the non-disclosure of negative data on antidepressants. They only publish positive studies, and the negative ones aren’t published. You then have a bias of infinity. There are hundreds of these things that go on.”

        His book also addresses the now infamous revolving door between the government and the drug industry. One classic example is Julie Gerberding, who headed up the Centers for Disease Control and Prevention (CDC)—an agency charged with overseeing vaccines and drug companies—for a number of years before becoming the president of Merck’s vaccine division.

        If you don't see the enormity of the influence her former high-level ties to the CDC can have, just consider the fact that Merck makes 14 of the 17 pediatric vaccines recommended by the CDC, and 9 of the 10 recommended for adults, and while vaccine safety advocates are trying to rein in the number of vaccines given to babies, safety concerns keep falling on deaf ears.

            “You should be banned forever from working with the industry if you’re in the position of authority making decisions about drugs and medications,” Dr. Kendrick says. “If we have to get opinion leaders and experts, people running studies, that’s fine. You can do that if you like. But you cannot then sit on the guideline committee.

            You cannot be the person who says, ‘This is how we’ll be treating X.’ Look at the cholesterol-lowering guidelines. How many conflicts of interest are there? Last time I looked at the guidelines made in 2004, there were 107 conflicts of interest, 70 directly with statin manufacturing companies. How can this be? This is nonsense.”

    More Information

        Anyone who’s a serious student of health needs a copy of Dr. Kendrick’s book, Doctoring Data: How to Sort Out Medical Advice from Medical Nonsense, in their library. It goes into far more details than we’ve covered in this interview. It’s definitively eye-opening, and will empower you to make sounder choices for you and your family when it comes to your health and lifestyle.

        It is an important tool to help you take control of your health and avoid deception by the media and drug companies. You don’t have to be fooled by drug industry manipulation once you know some of the tricks they use. Dr. Kendrick also has a blog, DrMalcolmKendrick.org, where he discusses this and other health-related topics. .

    Offline Iuvenalis

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    High-profile researcher admits fabricating scientific results published
    « Reply #7 on: September 23, 2015, 12:28:15 AM »
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  • Quote from: Jehanne
    Quote from: ascent
    Two journals, JAMA and Circulation Research, both said the paper was retracted after an internal analysis by Baker IDI Heart and Diabetes Institute "revealed anomalies that triggered an investigation which resulted in an admission of fabricated results by Dr Ahimastos".


    Yeah, people lie, even scientists.  So what?!  Point is that the scientific method guarantees that the truth will come out, eventually.


    This is adorable.

    Back when I "did science" (was in academia) I saw plenty of outright fraud. It was just sort of the way things were done, you gotta get funding and funding comes from *results*. It wasn't really a secret, I mean, we didn't mingle with the general public much so the language used to direct the results to a specific conclusion wasn't all that veiled.

    If you're still in the system you'll stick and move if someone asks pointed questions, but amongst academics it's not even considered unethical since you "just know" what is true a priori and you all agree on that.

    Anyway, you (Jehanne) worship the scientific method, and it's hilarious. Keep talking.



    Offline Jehanne

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    High-profile researcher admits fabricating scientific results published
    « Reply #8 on: September 23, 2015, 06:30:15 AM »
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  • Quote from: Iuvenalis
    Anyway, you (Jehanne) worship the scientific method, and it's hilarious. Keep talking.


    It's a tool to understand the natural world.  Digital computers did not exist 100 years ago; they do now.  The first modern digital computer, the ENIAC, could do 357 multiplications or 35 divisions per second:

    https://en.wikipedia.org/wiki/ENIAC

    (And, on a sidebar, note how all of the women in the article are dressed.)

    Modern computers have gotten much, much faster:

    https://en.wikipedia.org/wiki/Tianhe-2

    So, Science works; we won't be having this conversation otherwise.  And, I don't know that one can "pick and choose" among the various branches of science.

    P.S.  And, for those geocentrists, the Sun's motion through Earth's sky is anything but continuous:

    http://apod.nasa.gov/apod/ap150923.html