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Yes!  Eating ketchup was a killer for me- I used to drown everything in it. I didn't
realize how much HFCS I was pumping into my system.  I'm kind of used to not using condiments now, but when I must, I mix a little hot sauce with mayonaise

Beware that all commercially bottled mayonnaise widely marketed in the U.S.A., notably including "Hellman's Real Mayonnaise" (hah!), seem to contain needless sugar, the apparently only exception being the "Duke's" brand (yellow label).  My Mom recently reminded me that the home-made mayo used by much of the the W.W.-II Generation contained no sugar (i.e., raw eggs, vinegar, oil, lemon juice, and a little salt).

For readers more concerned with sodium than sugar, practically all commercially bottled hot sauce has huge amounts of salt.  There are exceptions, but finding them takes a lot of time reading the U.S.-mandated "ingredients" labels^[*].

or use an au jus sauce.  For a lot of people I'm sure a little BBQ sauce grilled into the meat or diced tomatoes wouldn't be harmful [....]

I mentioned diced tomatoes to get as much of the commercial tomato-sauce flavor while omitting the commercial de facto sugars and salt.  I don't know whether fresh tomatoes have a problematic amount of natural sugars; I confess ignorance about the natural-sugar content of other sauce-ingredient veggies (e.g., "sweet" bell peppers and onions).

You could mix up a sauce to your own taste, focused on a savory ingredient:
• pan-drippings, if not limited at all on intake of animal fats (when recipes direct the cook to "pour out drippings and discard all but 1 tbsp. fat", be contrary and save all the fat in a sanitized jar to be refrigerated for future use); or
• olive oil (‘extra-virgin’ for flavor).

That would be added to your sauce's more-or-less base ingredient:
• vinegar (I really like the savory taste of balsamic vinegar); or
• table wine (rice wine also has its enthusiasts); or
• beer (I use ‘stout’ in pan-gravy for red meat cooked to rare or med.-rare).

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Note [*]: Arguably worthwhile as a separate topic, so I don't intend to elaborate in this one.  CathInfo members can feel free to beat me to the original posting for it.

Fats paralyze insulin. Exercise and refraining from fats will prevent and cure Type 2 Diabetes. Then you won't need any Big Pharma pills.