Spouse, what do you mean it "works"? My mom's pills "worked" for 20 years or so, you see how that ended up. One day they stopped working and the crash was all the more horrific for being so long in coming.
It was clear her whole life was just various types of denial -- denying she'd ever have to retire, denying she'd ever be old, not seeking the purpose of existence. When everything caught up to her, the pills did nothing. Jesus talks about why when he distinguishes between the house built on sand, and the house built on the rock, on Himself. He didn't put you here to be happy on a pill; He wants to make you happy.
Maybe there are some people who really need some kind of tranquillizing pill, I'll admit someone who is psychotic probably needs that kind of treatment. But I'm just as certain that most of the millions of people who are popping antidepressants now do not have anything wrong with their brain chemistry. They are just giving into the weakness that all humans have without God. God builds us up by teaching us to suffer and carry the cross, but these quack doctors then come in and say "No! No crosses! Just grin like an idiot al the time and give me money for pills!" They are simply making people sick and weak and unable to stand on their own two feet. A prayer to St. James would be more effective for these people than Prozac, if they knew who St. James was.
I used to be a major neurotic spaz, so I know what I'm talking about. It was the way I grew up, the whole culture, the way we indulge ourselves and become soft, as well as our sins.
My belief is that, when the pill seems to be working, it's just kind of giving you a temporary fix. It's like slapping fresh paint on a decaying house. You need to go in and fix up the house first, in most cases. That is done by letting God rebuild us -- by circuмcising the heart. If you have a tendency to melancholia, you need to root it out, to do things that will help you overcome melancholia. Whatever is making you unhappy, go in and find it, then let Christ and Mary eliminate it from your soul. It is a kind of fatalism to just say "I'm a depressive" and leave it at that, as if you can't change with the help of God.