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Two Witnesses:  Dimond Brothers (not dead yet)
Antichrist:  JP2

One thing I've noticed about the Book of Revealtion (Apocalypse) is that it's not in chronological order.  It seems to make multiple passes over the same time period viewed from different persectives.  Both Chapter 14 and then later Chapter 18 speak about the fall of Babylon, the harlot, the beast, etc.

I just find it interesting that the Greek used the term "pharmakaia" ... typically rendered as sorcery or witchcraft, but it does come from the root word for a drug, from which we get out term "pharmacy".

God only know, but interesting nonetheless.

Fr. Sylvester Berry and Fr. Kramer ...

Fr Berry

In the foregoing chapter, St. John outlines the history of the Church from the coming of Antichrist until the end of the world in order to give a connected account of the two prophets, Elias and Enoch (or Moses), and the result of their labors. In this chapter, he shows us the true nature of that conflict. It shall be war unto death, between the Church and the powers of darkness, in a final effort of Satan to destroy the Church and thus prevent the universal reign of Christ on earth.

Satan will first attempt to destroy the power of the Papacy and bring about the downfall of the Church through heresies, schisms and persecutions that must surely follow. Failing in this, he will then attack the Church from without. For this purpose, he will raise up Antichrist and his prophet to lead the faithful into error and destroy those who remain steadfast.

The Church is ever in labor to bring forth children to eternal life. In the sad days here predicted, the sorrows and pains of delivery shall be increased many-fold. In this passage, there is an evident allusion to some particular son of the Church whose power and influence shall be such that Satan will seek his destruction at any cost. This person can be none other than the Pope to be elected in those days. The Papacy will be attacked by all the powers of hell. In consequence, the Church will suffer great trials and afflictions in securing a successor upon the throne of Peter.

...

The dragon is seen in heaven, which is here a symbol of the Church, the kingdom of heaven on earth. This indicates that the first troubles of those days will be inaugurated within the Church by apostate bishops, priests, and peoples---the stars dragged down by the tail of the dragon.

...

The dragon stands before the woman ready to devour the child that is brought forth. In other words, the powers of hell seek by all means to destroy the Pope elected in those days.

Fr Kramer

One aspect of the supreme conflict between Christ and Satan, between the Church and Antichrist has been depicted in chapter XI. The present chapter depicts another aspect of the same conflict showing Satan to have been active within the Church and to have won a notable following. But he is expelled, and the Church is purified and freed from all scandals. This struggle in the church is assumed as finished in XI. In point of time then, the happenings of the present chapter antedate those of chapter XI. Satan fails to destroy the Church from within, and that leads to the battle with the two beasts in the next chapter, where they, inspired, instigated and endowed by Satan, strive to destroy the Church from without. ...

2. The first vial is poured out upon earth to inflict malignant sores upon those who follow Antichrist. This resembles the sixth plague sent upon Egypt in which ''there came boils with swelling blains in men and beasts.''" God also threatened the unfaithful Jєωs in the wilderness with like punishment: "'May the Lord strike thee with a very sore ulcer in the knees and in the legs, and be thou incurable from the sole of the foot to the top of the head. Herod Arippa was similarly stricken when he allowed himself to be hailed as God.

In a moral sense this plague refers to the shame and confusion of those who harden their hearts and close their ears to the voice of the Church. In this sense it refers especially to the Jєωs who rejected the true Messias and become leaders against His Church in the days of Antichrist.

Verse 2

The first angel goes forth and pours out his bowl upon  the earth, upon the countries entirely subject and submissive to  Antichrist. He may actually carry a vial filled with blest water or  oil or some other matter used in divine service and may visibly  pour out the plague upon the earth, as did Moses sprinkling ashes  from a chimney upon the air. The effect is similar to that of Moses  sprinkling the ashes. The followers of the Beast are afflicted  by an incurable ulcer (See Jer. XXX. 12-15). It is “malignant”  in the technical sense. They may have disposed their bodies by  the corrupt and impure lives they led at the behest of the Beast and the False Prophet. But the angel directly causes the ulcer.  It may be like the ulcer with which God struck the Israelites for  adoring the golden calf. (Exod. XXXII. 35; Deut. XXVIII. 35).  The ulcer shall be extremely painful and bring confusion to  the adorers of the Beast, who shall be powerless to relieve them.  This is his first serious defeat. It is similar to the 6th plague  of Egypt.