There's a natural herbal medicine avalible OTC that's very effective for pain, especially chronic pain. It improves mood but without euphoic intoxication. Also known by the name Kratom. It behaves like a mu opidoid agonist, powerful prescription medication, but without the harsh side effects and risks.
There's different strains that work differently. One might improve mood, another manage pain better etc.
It can be brewed as a tea in crushed leaf form. Best method is to take powder form or in capsules and drink it down.
People who are on powerful prescription pain meds can sometimes completely transition to kratom.
It's something that should be explored for those who require daily OTC & prescription pain medicine.