Abstract

The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood. We use a proteotoxicity model based upon the inducible expression of Aβ in a human central nervous system nerve cell line to characterize a distinct form of nerve cell death caused by intracellular Aβ. It is shown that intracellular Aβ initiates a toxic inflammatory response leading to the cell's demise. Aβ induces the expression of multiple proinflammatory genes and an increase in both arachidonic acid and eicosanoids, including prostaglandins that are neuroprotective and leukotrienes that potentiate death. Cannabinoids such as tetrahydrocannabinol stimulate the removal of intraneuronal Aβ, block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accuмulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors.

I DESPISE any type of smoke...especially marijuana smoke.  Tobacco smoke from cigarettes, cigars, & pipes make me nauseous and sick to my stomach and trigger a vomit reaction...especially the “skunky” type of marijuana smoked today and the rank cigarette stink of “low-cost” cigarettes.   My home, my car, my EVERYTHING is smoke-free.  I’m all for small government and freedom,  EXECPT,  when it comes to those who’s smoking addiction/habit hold me hostage while I’m choking my brains out, gasping for breath and ready to pass out.   Sorry folks, I believe marijuana AND TOBACCO should be classed as schedule one illegal drugs.