The CIA MKULTRA programme was quite effective (from their point of view) in making mind-controlled slaves that would carry out any order.Project Monarch & Project Pandora are also of great interest. This isn't really new, the Old Man of the Mountain as he was called, Hasan as-Sabah subjected his followers to a form of mind control nearly 1,000 years ago. Using the right combination of torture, drugs, electric shocks, microwave radiation & who knows what else, they can break down most men to the point that they'll do just about anything that they're told.