Recombinant birth control vaccine
United States Patent 5733553
Abstract:
A recombinant birth control vaccine comprising a beta subunit of chorionic gonadotropin, a recombinant luteinizing hormone or a mixture thereof has been developed. This recombinant birth control vaccine may also act as a vaccine against a protein or peptide unassociated with the mammalian reproductive system, such as a protein or peptide associated with a disease organism such as hepatitis B.
Population is growing at a rapid pace in many economically developing countries and there is a continuing need of an alternate method for regulation of fertility. We proposed several years back a birth control vaccine which induces the formation of antibodies against the human pregnancy hormone, the human chorionic gonadotropin (hCG). These inventions are described in patents issued in India, U.S.A. and several other countries. (Ref. EP 204566, JP 62286928, CA 1239346, U.S. Pat. No. 4,780,312, CN 8603854). We describe now another invention which generates antibody response of a long duration against hCG after a single or a limited number of injections.