With regard to children, since the danger of death is often present and the only remedy available to them is the sacrament of baptism by which they are snatched away from the dominion of the devil and adopted as children of God, it admonishes that sacred baptism is not to be deferred for forty or eighty days or any other period of time in accordance with the usage of some people, but it should be conferred as soon as it conveniently can; and if there is imminent danger of death, the child should be baptized straightaway without any delay...

Though as a theologian Cajetan was a scholastic of the older Thomist type, his general position was that of the moderate reformers of the school to which Reginald Pole, later archbishop of Canterbury, also belonged; i.e.,  he desired to retain the best elements of the humanist revival in harmony with Catholic orthodoxy illumined by a revived appreciation of the Augustinian doctrine of justification. In the field of Thomistic philosophy, he showed striking independence of judgment, expressing liberal views on marriage and divorce, denying the existence of a material Hell and advocating the celebration of public prayers in the vernacular.
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Bruce Metzger wrote that Cajetan's biblical commentaries were surprisingly "modern", anticipating biblical textual criticism. Notably, Cajetan revived earlier Christian doubts as to the apostolic authorship of the Epistles of James, Jude, 2 John, and 3 John, as well as opposing Pauline authorship of the Epistle to the Hebrews.