Probably the same thing I don’t get about how I can lose grace by committing a mortal without the requisite full knowledge.
This is just the error of rationalism, since you are denying that one in the state of grace has a working conscience, a guardian angel, and the Holy Ghost's inspirations. St John tells us in John 1:9...
That was the true light (Christ), which enlighteneth every man that cometh into this world.
If all men (baptized and unbaptized) are enlightened by God when they are born, how much moreso, is one enlightened who is baptized and in the state of grace? Infinitely more.
One saint said that it could be a mortal sin if one did not say any prayers for a month. Isn't it also a mortal sin for one to miss Mass on Sundays/Holy Days? Even for a protestant, if they don't go to church, that's a mortal sin against the natural law and the 3rd commandment.
Children even as young as 3 can understand spiritual things, like guardian angels and God, etc. One who has reached the age of reason has a DUTY to do the basics (pray, attend church). If not, that's a mortal sin.
To say that God does not prompt all human beings to follow Him, to know Him, to worship Him is pure rationalism, naturalism and a denial of God's laws. If He sought fit to create such laws, then He will give everyone an opportunity to follow them. God does not command the impossible. God gives everyone a choice in this life. For there to be a choice, there must first be knowledge of what one is choosing - God vs not-God. And He infallibly gives everyone such a knowledge because He wants them to choose.