As per usual, my perspective is a theological one. Just by way of contrast, before my theological and doctrinal enlightenment, I was advocating for altar girls when I was a young kid in the Novus Ordo and had no clue.
In any case, I personally hold that it's inappropriate for women to be in the sanctuary due to the fact that it's a sacred space set aside for Liturgical actions, and (analogous to what took place in the Temple of the Old Testament), I hold that only clerics may enter the sanctuary, and that is in fact the primary Minor Order, the "Porter", permitting entry into the sacred liturgical space. Of course, I also hold that lay men should not be in the sanctuary and I advocate an restoration of permanent Minor Orders for those who would be permitted into the Sanctuary.
Sanctuary itself is not a huge space, and one of the duties of the Porter should in fact be to clean the Sanctuary, i.e. is not the same as having to clean the entire church, which is usually quite the ordeal. Most sanctuaries are hard floors that just require some dusting and occasional mopping and are relatively easy to maintain. Various altar linens and the like could be retrieved by a Porter and then handed off to whoever might be properly delegated to care for them.
Eroding the sacredness, the separation, of the sanctuary as the space set aside for the priestly action of the Holy Sactifice of the Mass IMO is just the beginning of the desacralization that led to loss of respect for the Sacred Liturgy in general. Even the angels tremble to enter into the sanctuary.
So, my opinion is that no one who does not at least have the Minor Order of Porter should be permitted to enter the Sanctuary, even outside of normal Liturgical functions, and that would obviously preclude women, and then any men who do not have the necessary Minor Order. Obviously of course there can be emergencies, etc. ... but they would be exceptions to the rule, just like a layman or lay woman may handle the Blessed Sacrament in some emergency, such as a fire or the like.