Naturally, gender confusion would lead to mental instability, abnormal ideation, even ѕυιcιdє in many cases. Even ignoring the fact that there is a demonstrable difference in the thought process of the sexes, you have a human being whose God-given biology has hardwired them according to their gender, yet the trauma of abuse, the pressures of their social situation, even, in their individualist infatuation, protecting their emotionally and spiritually masochistic lifestyle, compels them to act in contravention to it. Their conscious mind, blunted by sin, experiences frustration that their bodies will no cooperate with their deviance, prompting increasingly pronounced expressions of that deviance. Is it any wonder that this constant internal struggle would result in externalizations of of bizarre behavior, even self-harm?
The complementary, physical, sɛҳuąƖ, mental, emotional, spiritual, of the sexes; the practically universal proscription against acting against gender roles even amongst heathen religions; even the sɛҳuąƖ dimorphism present in humans and amongst most of the higher genera of creatures; all of these point to the difference between genders being properly ordered in fabric of Creation itself.