The saint was born in 1474 in the diocese of Verona. Early in life she dedicated herself to Christ as His bride. After the death of her parents, she desired to live solely for God in quiet and solitude, but her uncle insisted that she manage his household.  She renounced her patrimony in order to observe most perfectly the rule for Franciscan Tertiaries.

During a pilgrimage to the Holy Land in 1524, she lost her eyesight temporarily. Pope Clement VII, whom she visited in Rome, desired her to remain in the Holy City. Later she founded a society for girls, under the protection of St. Ursula; this was the beginning of the Ursuline Order. St. Angela was almost seventy when she died; her body remained incorrupt for thirty days. Remarkable phenomena occurred at her burial in the Church of St. Afra.

http://www.catholicculture.org/culture/liturgicalyear/calendar/day.cfm?date=2016-01-27

I say that St Angela is an American saint because she is the founder of a community of women religious with a presence in the United States since 1727.

St. Katharine Drexel
Katharine Drexel was born in Philadelphia in 1858. She had an excellent education and traveled widely. As a rich girl, she had a grand debut into society. But when she nursed her stepmother through a three-year terminal illness, she saw that all the Drexel money could not buy safety from pain or death, and her life took a profound turn.

She had always been interested in the plight of the Indians, having been appalled by reading Helen Hunt Jackson's A Century of Dishonor. While on a European tour, she met Pope Leo XIII and asked him to send more missionaries to Wyoming for her friend Bishop James O'Connor. The pope replied, "Why don't you become a missionary?" His answer shocked her into considering new possibilities.

Back home, she visited the Dakotas, met the Sioux leader Red Cloud and began her systematic aid to Native American missions.

She could easily have married. But after much discussion with Bishop O'Connor, she wrote in 1889, "The feast of Saint Joseph brought me the grace to give the remainder of my life to the Indians and the Colored." Newspaper headlines screamed "Gives Up Seven Million!"

After three and a half years of training, she and her first band of nuns (Sisters of the Blessed Sacrament for Indians and Colored) opened a boarding school in Santa Fe. A string of foundations followed. By 1942 she had a system of African American Catholic schools in thirteen states, plus forty mission centers and twenty-three rural schools. Segregationists harassed her work, even burning a school in Pennsylvania. In all, she established fifty missions for Native Americans in sixteen states.

Two saints met when she was advised by Mother Cabrini about the "politics" of getting her order's rule approved in Rome. Her crowning achievement was the founding of Xavier University in New Orleans, the first university in the United States for African Americans.

At seventy-seven, she suffered a heart attack and was forced to retire. Apparently her life was over. But now came almost twenty years of quiet, intense prayer from a small room overlooking the sanctuary. Small notebooks and slips of paper record her various prayers, ceaseless aspirations and meditation. She died at ninety-six and was canonized in 2000.

http://www.catholicculture.org/culture/liturgicalyear/calendar/day.cfm?date=2016-03-03