To doubt this would be to doubt the assurance of Jesus in the Gospel,
Mk 10:28 And Peter began to say unto him: Behold, we have left all things, and have followed thee. 29 Jesus answering, said: Amen I say to you, there is no man who hath left house or brethren, or sisters, or father, or mother, or children, or lands, for my sake and for the gospel, 30 Who shall not receive an hundred times as much, now in this time; houses, and brethren, and sisters, and mothers, and children, and lands, with persecutions: and in the world to come life everlasting.
God, as the Saints say, "cannot be outdone in generosity". Whenever we give up anything for God, it comes back to us a thousandfold, often in this life itself, at least in terms of the peace and joy of Christ that accompanies a holy life. Those who are going through tough times with help, prayer and encouragement should persevere. The reward God promises and that they will assuredly have will be proportionately great for those who face material or other hardships in the course of carrying their daily cross. The same when evildoers seem to prosper, as the Psalmist says, esp. in Psalm 72. King David says he could not understand this, until he perceived it in light of their last end. St. Thomas says as well that God allows difficulty to come to some in this life, but those who in this life seem to have less chastisements will face severe and everlasting punishment in the end.